Gardner’s Syndrome

Gardner’s Syndrome is a rare genetic disorder.
it usually causes benign or non cancerous growths. It is classified as a subtype of
adenomatous polyposis which causes colon cancer. Gardner’s Syndrome can lead to growth on various
areas of the body. Tumors are most commonly found in the colon, sometimes in large numbers.
In addition to polyps on the colon, growths can develop, including fibromas, desmoid tumors
and sebaseous cycts, which are fluid filled growths under the skin. The condition is considered
rare, it occurs in about 1 in 8,000 people. The syndrome is a genetic condition, which
means it is inherited. The adenomatous polyposis coli (APC) gene produces APP protein. APC
protein regulates cell growth and prevents cells from dividing too fast. People with
Gardner’s Syndrome have a defect in the APC gene. This affects cell growth, which leads
to the abnormal tissue growth.What causes the mutation of the gene has not been determined.
the main risk factors for developing Gardner’s Syndrome is having at least one parent with
the condition. The main symptom of Gardner’s Syndrome is
multiple growths in the colon. The growths are also known as polyps. Although the number
of growths varies, they can be in the hundreds. In addition to growth on the colon, extra
teeth can develop along with bony tumors on the skull.
another common symptom of Gardner’s Syndrome is cycts, which can form under the skin on
various parts of the body. Fibromas and epithelial cycts are common.
People with syndrome also have a higher risk of developing colon cancer.
Symptoms may suggest Gardner’s Syndrome. A doctor may use a blood test to check for the
syndrome if multiple colon polyps or other symptoms have been detected. A blood test
for Gardner’s Syndrome determines if there is an APC gene mutation.
Because people with Gardner’s Syndrome have a higher risk of developing colon cancer,
treatment is usually aimed at preventing this. Medications such as a COX2 inhibitor may be
used to limit the growth of colon polyps. But the medication s not always successful.
Treatment also involves close monitoring of the polyps to make sure the do not become
malignant. In some cases, removal of the colon may be
recommended in order to prevent colon cancer from developing. if dental abnormalities are
present – treatment may be recommended to correct those problems.
As with all medical conditions, a healthy lifestyle with proper nutrition, exercise
and stress reduction activities can help people with a syndrome to cope with related physical
and emotional issues. The prognosis for people with Gardner’s Syndrome
varies, depending on the severity of symptoms. According to Standford Medicine, people who
have an APC gene mutation such as Gardner’s Syndrome, have an increasingly high chance
of developing colon cancer as they age. Without surgical treatment, almost all people with
the APC gene mutation will develop colon cancer by age 40. Genetic testing is possible to
determine if a person carries the gene mutation. Since the condition is inherited there is
no way to prevent it.

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