New Targets in Breast Cancer Fight

New Targets in Breast Cancer Fight


Speaker 1: Every year, 250,000 or more women
will be given a diagnosis of breast cancer and about 40,000 of them are expected to die.
Cancer is abnormal development, so in order to understand cancer, we really have to understand
the processes that lead to normal development, and then we will be able to dissect those
to understand how they have gone array to lead to the abnormal development that creates
the cancer which is the danger to human health. Speaker 2: A hallmark of cancer is that they
have acquired some level of a growth factor independence. But they’re not completely
growth factor independent. They have requirements, they have growth factor requirements. They
have requirements to contact their neighbors or contact their matrix that’s underneath
them. And all of these things might be required for cancers and might be a potential target. By looking at the embryo, we’ve uncovered
a large number of them that are active during these prolific embryonic stages, that we have
now found or are also active in cancers. And those provide new targets. Speaker 1: We think that some of the signatures
that we’ve identified in these cells were going to try to convert them into strategies
for early detection. And then of course, detecting early and knowing what you’re dealing with,
having the person’s fingerprint on their cancer, will enable us to treat that person as the
individual they are, hopefully causing minimal toxicity and maximal benefit. What we’re
interested in is the translation of our basic research understanding to improve human health,
which is what the Salk Institute is all about.

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