Signs and Symptoms of Mast Cell Activation Syndrome

Signs and Symptoms of Mast Cell Activation Syndrome

Hi, Eric Bakker, naturopath from way down
under, from New Zealand. Thanks for coming back, we’re talking about
Mast Cell Activation Syndrome. I’m doing a few videos on this particular
topic today. Let’s look at the signs and symptoms of Mast
Cell Activation Syndrome. We spoke about the white blood cells, the
mast cells releasing chemicals. These things contain what we call granules,
they become granulated. They swell up. They contain different chemicals which they
will release into the environment depending on the trigger. Some of these chemicals will increase permeability,
for example of blood vessels, leading to swelling, congestion, inflammation, maybe itching of
the skin, underlying areas where these blood vessels are. Other things that you’re going to find will
be increased mucous production. This will commonly occur, too, with histamine,
with too much histamine secretion. This mucous is produced in response to a stimulation,
which could lead to sinus and sneezing and congestion, and blocked nose, and post-nasal
drip and all kinds of problems. The other one which I want to talk about is
the contraction of smooth muscle. Some of these chemicals called cytokines release
specific chemicals called interleukins and these can be pro-inflammatory or anti-inflammatory. Some interleukins will stimulate the contraction
for example of muscles. This can lead to cramping, for example, cramping
pain of the digestive system. You know, oh, I’ve got a cramp in my gut,
what the hell is going on. It could be bladder problems, it could be
bowel problems. So contraction of smooth muscle is not uncommon
when we’ve got this mast cell activation, and people will think they’ve got a parasite
or Candida, when in fact they could well have this contraction of the smooth muscle going
on there. Bladder as well, there could be a bladder
spasm going on there. All these things are smooth muscle. The intestines are smooth muscle, in they
can be affected by chemicals produced in too high amount. If you look at some of the typical signs and
symptoms, I’ll just read off the checklist here. Typical ones: skin rashes and hives are very
common. Swelling and edema, remember we talked about
the blood vessels. Also they can leak more so you get more fluid
leaking out of them which can cause more swelling. As we talked about the increased permeability
caused by the syndrome. Flushing. Itching of the skin. Prickling of the skin. Abdominal pain and cramping. We talked about the smooth muscle contraction. Nausea. Some people can even get a bit sick if the
stomach gets involved in this area as well. Diarrhea. Loose bowels. Some people can even get constipation or diarrhea
or have irritable bowel syndrome as a result of this particular syndrome. Wheezing. Shortness of breath. Heart palpitations. Anxiety. Poor concentration. Low blood pressure. Fatigue. There’s even a tachycardia in a particular
syndrome. A fast heart beating syndrome has been attributed
to mast cell activation problems. All of these things can be as a result of
chemicals released by these cells called mast cells. More and more I’m noticing this in patients
that are not responding to normal therapies where we have to start looking at taking particular
foods out or changing the patient’s environment to damp down this overreaction of the mast
cells. We’ll talk about that in a subsequent video. I think I’ve mentioned these things. Hives, swelling, flushing, nausea, low blood
pressure. Some people can even faint, get very dizzy
and even faint. Red eyes is another one I forgot to mention. In the past I’ve mistakenly looked at this
syndrome and thought that the patient had adrenal fatigue when in fact I had a mast
cell activation problem. I hope that gives you a bit of information
on the signs and symptoms of this problem. Thanks for tuning in.


  1. Hi doctor Becker my name is Ernie Valencia I’m 19 from the US and I’m having trouble with nutrition with giardia. I just started a cleanse three days ago on the full moon and have a a almost 0 sugar diet about 3 grams or less a day and gluten free diet. I’m taking cloves oregano bee propolis iodine and colloidal silver the infection has made me lactose intolerant and I’m having neurological symptoms along with weight loss. Will the absorption of nutrients get better as the infection dies??

  2. Hello Eric,
    Thank you for these precious videos,
    .Does having a pet may cause any problems for candida or other things?
    .Some antifungal medicines described by doctors has lactose in ingredients,whats the logic in it?Is using prebiotic s with anti fungal medicine a good idea?
    .Are we likely sharing same yeast problems with the spouses,?
    Best Regards ! From Turkey

  3. Hello. Thanks for the video. Up until three years ago, I took Quetiapine (long story) for 3 years prior to that. I now get lots of fatigue and heart pain. I noticed that the endocannabinoid system in the body coexists beside histamine receptors, so I am thinking that my histamine regulation is having trouble adjusting to life without Quetiapine (it was originally given to me as an antipsychotic, I don't take or seemingly need them now), I have a small benign tumour in my foodpipe and tend to have trouble with peristalsis, I near choked a few times. Also I was born with signs of leukemia, in a country (ireland) that has fluoridated tap water, so I imagine that dampens my general reactions in the first place. I am worried about choking on food, and of having a heart attack. I am only 33. All I can say is, understanding chemical biology in the body (and brain) and avoiding stress are literally what keep my heart ticking over these days! And because I had a mild psychosis years ago, my doctor seems to not believe that I have heart pain. I get accused of being an hypochondriac! She has said "I don't know" so often, I have to rely on videos like this to help me understand these sets of symptoms.

  4. Think I may have it not had it looked at yet so worried one question will it kill me some one get back to me so worried

  5. Great video.
    Question: why would people think they have candida if they actually have contraction of the smooth muscle?

  6. I just found out that I have a rare form of Mast cell disease called Telangietasia Macularis Eruptiva Perstans. I have ALL of the symptoms you spoke about!!

  7. Thank you for talking about this serious but little known illness. It stole my old life & I am working on living a meaningful life despite being mostly housebound & many days bedridden. This is a secondary illness, as I have cycled through remission/relapse of ME/CFS for many years. I was once a dancer who cross trained & led a very active life. UGH!

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