Women’s Health Study Questions Answered by a NAMS practitioner

Women’s Health Study Questions Answered by a NAMS practitioner


the Women’s Health Initiative study was
a really important study actually it was the largest study of its kind it cost o
millions and millions of dollars to do this study but the purpose of it was to
show the authors of the study thought they were going to show the benefits of
hormone replacement therapy for most women right they really figured they
were going to see all advantages and nothing bad when the Women’s Health
Initiative study results came out they were surprised because there were some
adverse events that they weren’t expecting so there was a small increase
in breast cancer there was a small increase in the risk
of heart attack and stroke so the study was stopped prematurely but when data
was broken down there were definitely issues with the study so for one thing
on average women in the study were 63 years old well as we think that most
women go through menopause in the early 50s that’s a long way out from their
menopause being 63 that’s the average age of women in the study women in the
study were not suffering from any symptoms of hot flashes at all and also
they were using conjugated estrogen in the study and they were also using a
synthetic progestin so things that are not considered natural bioethical
hormones right so there was some definitely some flaws with the Women’s
Health Initiative so unfortunately when the results came out they were plastered
all over the newspaper it was you know all doom and gloom and women really
stopped their hormones at that point doctors got really scared and the whole
thing was painted kind of black that it was all bad but the details hadn’t been
really looked at yet so as the story evolved we’ve got it with the flaws in
the study were and nowadays you know women are offered different hormones
they’re offered them closer to their menopause and it’s done a lot
differently without these large standard doses of synthetic hormones that women
were given now we would give you know smaller doses of bioidentical hormones
and closer monitoring so remember that women in the study were on average 63
okay so we we think and basically know that estrogen is protective for heart
disease so women have less risk less issues in terms of heart attack and
stroke before their menopause once menopause hits and we lose our estrogen
Ashton seems to to help keep our vessels clean of plaque so once we lose estrogen
that plaque starts to develop and you get vessels that have more more plaque
more narrowing and all of a sudden if you give an oral estrogen and we’re
talking oral estrogen because the studies don’t show the same with
transdermal estrogen but if you give an oral estrogen in that older demographic
then that a thorough scar like plaque that can rupture that can break off and
you can end up with a heart attack or a stroke so that’s really the issue first of all we should know that women
there was like a couple different arms to this study some women received
estrogen alone and some received estrogen and progestin alone
the estrogen only arm they did not have an increased risk of breast cancer at
all it was the estrogen and progestin arm
that did and it was such also a very small amount of increased risk legs
there was an extra eight per 10,000 women I think I think was was the exact
data that had that increased breast cancer so it was very small but still
considered significant but it seemed to be basically the synthetic progestin
that was really the issue not the estrogen alone certainly the the positives would be the
things you’d expect women of course would have hot flash resolution if they
had any hot flashes remember remember I did say that most women in the study
were hot flash free to begin with of course they had positive effect on bones
so it really affected the bump bones and osteoporosis risk in a beneficial way oral estrogens together whether they’re
synthetic or they’re bioidentical they do have some some problematic risks so
they can increase your clotting risk once the estrogen goes through the
stomach and the liver it increases clotting factors so there
is more risk of stroke especially and this is very important if you’re with
it’s usually within the first two years of starting oral estrogen after that two
year window the risk of a stroke decreases actually I should say
decreases it does not increase bioidentical progesterone has really no
risk in terms of heart attacks stroke don’t think there’s any risk in terms of
breast cancer either an orally biotechnical progesterone is very nice
it doesn’t really have any adverse effects synthetic progestin progestin
absolutely will affect mood in a negative way it affects triglycerides
will increase triglycerides which are a lipid and the blood oral progesterone
doesn’t and it symptoms to calm the body down helps women with sleep irritability
mood you know protects the endometrium protects the breasts as well from
estrogen proliferation that’s a really good question what what
they found is you know if the synthetic hormones are used in small doses for
short periods of time the side-effects maybe aren’t quite so bad but if they
used in larger doses long periods of time there’s definitely risk so I’d like
to see them not used because there are so many better options there is the
elite trial which is ongoing right now the keep study came out in October 2012
those results and it was just a four-year study and looked at the risk
of you know using bioidentical hormones early on in the menopause so women were
51 in that in that study and the results over four years were quite good there
was no increased risk of breast cancer annoying case risk of heart attacks or
stroke in the group and they were using a transdermal bioidentical estrogen and
by identical progesterone in that study but the elite trial it’s still being
being conducted

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